Characteristics of community-acquired respiratory viruses infections except seasonal influenza in transplant recipients and non-transplant critically ill patients

Transplant recipients are vulnerable to life-threatening community-acquired respiratory viruses (CA-RVs) infection (CA-RVI). Even if non-transplant critically ill patients in intensive care unit (ICU) have serious CA-RVI, comparison between these groups remains unclear. We aimed evaluate clinical characteristics and mortality of CA-RVI except seasonal influenza A/B transplant ICU. collected 37,777 CA-RVs multiplex real-time reverse transcription-polymerase chain reaction test results individuals aged ?18 years from November 2012 2017. The tests included adenovirus, coronavirus 229E/NL63/OC43, human bocavirus, metapneumovirus, parainfluenza virus 1/2/3, rhinovirus, syncytial A/B. found 286 cases, including 85 solid organ transplantation (G1), 61 hematopoietic stem cell (G2), 140 ICU (G3), excluding those with repeated isolation within 30 days. Adenovirus positive rate cases were most prominent G2 ( p < 0.001). median time interval was 20 months G1 G2, respectively. All-cause in-hospital significantly higher G3 than or (51.4% vs. 28.2% 39.3%, = 0.002, respectively). mechanical ventilation (MV) the independent risk factor associated all-cause all three (hazard ratio, 3.37, 95% confidence interval, 2.04–5.56, This study highlights importance diagnosis even long-term posttransplant period, MV.